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Industrial Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator

Industrial Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator

  • High Light

    high shear mixer granulator

    ,

    tablet granulation machine

  • Material
    SUS304 SUS316L Food Grade GMP
  • Standard
    GMP
  • Product
    Granules
  • Cutter
    Speed Viable
  • Color
    Stainless Steel
  • Voltage
    380V 220V 400V 415V
  • Granule Size
    0.2mm- 2mm
  • Principle
    Rapid Mix And Cut
  • Name
    Pharmaceutical Rapid Mix Granulator
  • Place of Origin
    China
  • Certification
    SGS CE ISO
  • Model Number
    GHL
  • Minimum Order Quantity
    1units
  • Price
    USD1900-3890 per unit
  • Packaging Details
    plywood or shipping container
  • Delivery Time
    25 working days
  • Payment Terms
    Western Union, MoneyGram, D/A, L/C, D/P, T/T
  • Supply Ability
    1000units per year

Industrial Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator

Industrial Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator

 

1. Overview of granulation and characteristics of pharmaceutical rapid mix granulator

 

1.1 Common methods of granulation and their respective characteristics

 

Granulation is often carried out by wet granulation, one-step granulation and dry granulation. Granulation is a process in which a powder of a raw material and a binder are mixed into a soft material, and the particles are dried. However, the soft material is traditionally made of a soft material made of a trough mixer and then wetted by a rocking granular mechanism. However, it is dried into a dry granule by a drying box. This method has low yield, high strength, serious pollution, and long production cycle. The equipment covers a large area. Recently, it has been gradually replaced by a continuous production operation method or a one-step granulation method of high-speed wet granulation and boiling-dry granulation.

 

1.1.1 trough mixing + rocking granulation

 

The traditional trough mixing + swing granulation process is characterized by relatively independent process and low cost. The disadvantages are low production efficiency, high labor intensity, many dead zones in the tank, easy cross-contamination, high dust pollution, and forming effect. Poor, poor fluidity and large difference in tablet weight.

 

1.1.2 pharmaceutical rapid mix granulator/ wet granulation

 

Today's wet granulation equipment has been developed into high-speed wet granulation, and the high-speed mixing granulator is the fastest and most widely used granulation equipment in recent years, and it is also the most economical. It combines the mixing and granulation process and is carried out in a fully enclosed container. It is characterized by saving time and meeting GMP requirements, good mixing effect, high production efficiency, good particle and sphericity, good fluidity, easy cleaning and no pollution, stable content and low energy consumption. It is a kind of equipment with large amount of granulation, fast speed, good granules and low energy consumption, which is very popular among users. At present, several solid preparation processes have accounted for 70% of all solid preparation granulation equipment. However, it has certain requirements for the granulated materials.

 

1.1.3 one-step granulation

 

One-step granulation (also called fluidized bed granulation) integrates mixing, granulation and drying, and the granulated finished granules are relatively loose, with a particle size of about 40-80 mesh. It is characterized by high production efficiency, low labor intensity, low external pollution and neat tidying of finished products. The disadvantage is that the power consumption is high and the control parameters vary from species to species.

 

1.1.4 Dry granulation

 

Dry granulation is carried out by pressing a powder mixture into a large piece and then pulverizing and granulating to prepare granules of a desired particle size, which is suitable for a moist heat sensitive drug. Dry granulation equipment is characterized by less equipment required, small floor space, time and labor saving, and the tablet is easily disintegrated due to the absence of binder in granulation. The disadvantage is that the "dumping dust" is serious when the tablet is pressed, and the cross-contamination is easily caused, and the dissolution rate of the pressed particles is slow, so it is not suitable for the water-soluble drug.

 

 

Technical Parameter

Type A B C×D E F
50 320 950 1250×800 970 1650
150 420 1000 1350×800 1050 1750
200 500 1100 1650×940 1450 2050
250 500 1160 1650×940 1400 2260
300 550 1200 1700×1000 1400 2310
400 670 1300 1860×1100 1550 2410
600 750 1500 2000×1230 1750 2610

 

Name Type
50 150 200 250 300 400 600
Volume L 50 150 200 250 300 400 600
output capacity kg/batch 15 50 80 100 130 200 280
admix speed r.p.m 200/400 180/270 180/270 180/270 140/220 106/155 80/120
admix power kw 4/5.5 6.5/8 9/11 9/11 13/16 18.5/22 22/30
cutting speed r.p.m 1500/3000 1500/3000 1500/3000 1500/3000 1500/3000 1500/3000 1500/3000
cutting power kw 1.3/1.8 2.4/3 4.5/5.5 4.5/5.5 4.5/5.5 6.5/8 9/11
compressed air consumption m3/min 0.6 0.9 0.9 0.9 1.1 1.5 1.8
weight kg 500 800 1000 1300 1800 2200 2600