50-600L Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator

50-600L Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator

Product Details:

Place of Origin: China
Certification: SGS CE ISO
Model Number: GHL

Payment & Shipping Terms:

Minimum Order Quantity: 1units
Price: USD1900-3890 per unit
Packaging Details: plywood or shipping container
Delivery Time: 25 working days
Payment Terms: Western Union, MoneyGram, D/A, L/C, D/P, T/T
Supply Ability: 1000units per year
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Detail Information

Material: SUS304 SUS316L Food Grade GMP Standard: GMP
Product: Granules Cutter: Speed Viable
Color: Stainless Steel Voltage: 380V 220V 400V 415V
Granule Size: 0.2mm- 2mm Principle: Rapid Mix And Cut
Name: Pharmaceutical Rapid Mix Granulator
High Light:

600L wet granulation machine


50L rapid mixture granulator

Product Description

Industrial Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator


1. Overview of granulation and characteristics of pharmaceutical rapid mix granulator


1.1 Common methods of granulation and their respective characteristics


Granulation is often carried out by wet granulation, one-step granulation and dry granulation. Granulation is a process in which a powder of a raw material and a binder are mixed into a soft material, and the particles are dried. However, the soft material is traditionally made of a soft material made of a trough mixer and then wetted by a rocking granular mechanism. However, it is dried into a dry granule by a drying box. This method has low yield, high strength, serious pollution, and long production cycle. The equipment covers a large area. Recently, it has been gradually replaced by a continuous production operation method or a one-step granulation method of high-speed wet granulation and boiling-dry granulation.


1.1.1 trough mixing + rocking granulation


The traditional trough mixing + swing granulation process is characterized by relatively independent process and low cost. The disadvantages are low production efficiency, high labor intensity, many dead zones in the tank, easy cross-contamination, high dust pollution, and forming effect. Poor, poor fluidity and large difference in tablet weight.


1.1.2 pharmaceutical rapid mix granulator/ wet granulation


Today's wet granulation equipment has been developed into high-speed wet granulation, and the high-speed mixing granulator is the fastest and most widely used granulation equipment in recent years, and it is also the most economical. It combines the mixing and granulation process and is carried out in a fully enclosed container. It is characterized by saving time and meeting GMP requirements, good mixing effect, high production efficiency, good particle and sphericity, good fluidity, easy cleaning and no pollution, stable content and low energy consumption. It is a kind of equipment with large amount of granulation, fast speed, good granules and low energy consumption, which is very popular among users. At present, several solid preparation processes have accounted for 70% of all solid preparation granulation equipment. However, it has certain requirements for the granulated materials.


1.1.3 one-step granulation


One-step granulation (also called fluidized bed granulation) integrates mixing, granulation and drying, and the granulated finished granules are relatively loose, with a particle size of about 40-80 mesh. It is characterized by high production efficiency, low labor intensity, low external pollution and neat tidying of finished products. The disadvantage is that the power consumption is high and the control parameters vary from species to species.


1.1.4 Dry granulation


Dry granulation is carried out by pressing a powder mixture into a large piece and then pulverizing and granulating to prepare granules of a desired particle size, which is suitable for a moist heat sensitive drug. Dry granulation equipment is characterized by less equipment required, small floor space, time and labor saving, and the tablet is easily disintegrated due to the absence of binder in granulation. The disadvantage is that the "dumping dust" is serious when the tablet is pressed, and the cross-contamination is easily caused, and the dissolution rate of the pressed particles is slow, so it is not suitable for the water-soluble drug.



Technical Parameter

Type A B C×D E F
50 320 950 1250×800 970 1650
150 420 1000 1350×800 1050 1750
200 500 1100 1650×940 1450 2050
250 500 1160 1650×940 1400 2260
300 550 1200 1700×1000 1400 2310
400 670 1300 1860×1100 1550 2410
600 750 1500 2000×1230 1750 2610


Name Type
50 150 200 250 300 400 600
Volume L 50 150 200 250 300 400 600
output capacity kg/batch 15 50 80 100 130 200 280
admix speed r.p.m 200/400 180/270 180/270 180/270 140/220 106/155 80/120
admix power kw 4/5.5 6.5/8 9/11 9/11 13/16 18.5/22 22/30
cutting speed r.p.m 1500/3000 1500/3000 1500/3000 1500/3000 1500/3000 1500/3000 1500/3000
cutting power kw 1.3/1.8 2.4/3 4.5/5.5 4.5/5.5 4.5/5.5 6.5/8 9/11
compressed air consumption m3/min 0.6 0.9 0.9 0.9 1.1 1.5 1.8
weight kg 500 800 1000 1300 1800 2200 2600


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