50-600L Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator
|Place of Origin:||China|
|Certification:||SGS CE ISO|
Payment & Shipping Terms:
|Minimum Order Quantity:||1units|
|Price:||USD1900-3890 per unit|
|Packaging Details:||plywood or shipping container|
|Delivery Time:||25 working days|
|Payment Terms:||Western Union, MoneyGram, D/A, L/C, D/P, T/T|
|Supply Ability:||1000units per year|
|Material:||SUS304 SUS316L Food Grade GMP||Standard:||GMP|
|Color:||Stainless Steel||Voltage:||380V 220V 400V 415V|
|Granule Size:||0.2mm- 2mm||Principle:||Rapid Mix And Cut|
|Name:||Pharmaceutical Rapid Mix Granulator|
600L wet granulation machine,
50L rapid mixture granulator
Industrial Wet Granulation Machine , Pharmaceutical Rapid Mixture Granulator
1. Overview of granulation and characteristics of pharmaceutical rapid mix granulator
1.1 Common methods of granulation and their respective characteristics
Granulation is often carried out by wet granulation, one-step granulation and dry granulation. Granulation is a process in which a powder of a raw material and a binder are mixed into a soft material, and the particles are dried. However, the soft material is traditionally made of a soft material made of a trough mixer and then wetted by a rocking granular mechanism. However, it is dried into a dry granule by a drying box. This method has low yield, high strength, serious pollution, and long production cycle. The equipment covers a large area. Recently, it has been gradually replaced by a continuous production operation method or a one-step granulation method of high-speed wet granulation and boiling-dry granulation.
1.1.1 trough mixing + rocking granulation
The traditional trough mixing + swing granulation process is characterized by relatively independent process and low cost. The disadvantages are low production efficiency, high labor intensity, many dead zones in the tank, easy cross-contamination, high dust pollution, and forming effect. Poor, poor fluidity and large difference in tablet weight.
1.1.2 pharmaceutical rapid mix granulator/ wet granulation
Today's wet granulation equipment has been developed into high-speed wet granulation, and the high-speed mixing granulator is the fastest and most widely used granulation equipment in recent years, and it is also the most economical. It combines the mixing and granulation process and is carried out in a fully enclosed container. It is characterized by saving time and meeting GMP requirements, good mixing effect, high production efficiency, good particle and sphericity, good fluidity, easy cleaning and no pollution, stable content and low energy consumption. It is a kind of equipment with large amount of granulation, fast speed, good granules and low energy consumption, which is very popular among users. At present, several solid preparation processes have accounted for 70% of all solid preparation granulation equipment. However, it has certain requirements for the granulated materials.
1.1.3 one-step granulation
One-step granulation (also called fluidized bed granulation) integrates mixing, granulation and drying, and the granulated finished granules are relatively loose, with a particle size of about 40-80 mesh. It is characterized by high production efficiency, low labor intensity, low external pollution and neat tidying of finished products. The disadvantage is that the power consumption is high and the control parameters vary from species to species.
1.1.4 Dry granulation
Dry granulation is carried out by pressing a powder mixture into a large piece and then pulverizing and granulating to prepare granules of a desired particle size, which is suitable for a moist heat sensitive drug. Dry granulation equipment is characterized by less equipment required, small floor space, time and labor saving, and the tablet is easily disintegrated due to the absence of binder in granulation. The disadvantage is that the "dumping dust" is serious when the tablet is pressed, and the cross-contamination is easily caused, and the dissolution rate of the pressed particles is slow, so it is not suitable for the water-soluble drug.
|output capacity kg/batch||15||50||80||100||130||200||280|
|admix speed r.p.m||200/400||180/270||180/270||180/270||140/220||106/155||80/120|
|admix power kw||4/5.5||6.5/8||9/11||9/11||13/16||18.5/22||22/30|
|cutting speed r.p.m||1500/3000||1500/3000||1500/3000||1500/3000||1500/3000||1500/3000||1500/3000|
|cutting power kw||1.3/1.8||2.4/3||4.5/5.5||4.5/5.5||4.5/5.5||6.5/8||9/11|
|compressed air consumption m3/min||0.6||0.9||0.9||0.9||1.1||1.5||1.8|